hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects

Massachusetts General Hospital99 enrolled

Overview

Vitamin D deficiency (low levels of vitamin D in the blood) is a common problem. A recently discovered protein, called hCAP18, likely plays an important role in the immune system and may depend on adequate levels of vitamin D. It is not known what levels of vitamin D are needed to allow the body to make this protein. Nor is it known if giving vitamin D to people who are found to be deficient will help boost levels of hCAP18. This study aims to clarify the relationship between vitamin D levels and hCAP18.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Healthy Subjects Vitamin D Deficiency

Interventions

ergocalciferolDRUG

Ergocalciferol 50,000 IU given every other day for 5 total doses

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-80 Exclusion Criteria: * Known active infectious disease or chronic inflammatory disorder * Hypercalcemia * Chronic kidney disease * Pregnancy

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

hCAP18 Levels

Time frame: Baseline

Baseline 25-OH Vitamin D Level

Time frame: Baseline

Data from ClinicalTrials.gov

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