Resistance on Antithrombotic Drugs in Ischemic Heart Disease

University of Zagreb141 enrolled

Overview

The purpose of this study is to determine whether aspirin and clopidogrel resistance measured with Multiplate function analyser has a good correlation with incidence of major adverse cardiac events in patients with coronary artery disease (CAD).

Our plan is to enroll 180 patients with diagnosed CAD who electively undergo percutaneous coronary intervention (PCI). Blood samples will be taken just before the procedure and one day after the procedure and analysed on Multiplate function analyser. Assessing aspirin and clopidogrel resistance incidence using Multiplate platelet function analyzer we will also try to find resistance correlation with the incidence of major adverse cardiac events in a one year follow up.

Study Type

OBSERVATIONAL

Enrollment

141

Conditions

Coronary Artery Disease

Interventions

PCIPROCEDURE

percutaneous coronary intervention in stable coronary artery disease

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Elective PCI * \> 7 days on aspirin 100mg therapy before the intervention * \> 7 days on clopidogrel 75mg therapy before the intervention Exclusion Criteria: * Loading dose of clopidogrel * \< 7 days on aspirin therapy before the intervention * Myocardial infarction less than 30 days before the intervention * Cerebrovascular incident less that three months before the intervention * Haemorrhagic diathesis * Trc \< 100 * Htc \< 30% * Creatinine \> 140

Locations (1)

Clinic of Cardiovascular Diseases, Clinical Medical Centre Rebro

Zagreb, Croatia

Outcomes

Primary Outcomes

Major adverse coronary event

Time frame: 12 months

Data from ClinicalTrials.gov

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