Juvista in Scar Revision Surgery of Disfiguring Scars

Inclusion Criteria: * Patients aged 18-85 years who have provided written informed consent. * BMI between 15 and 35 kg/m2 * Patients with, in the opinion of the Investigator, clinically acceptable results for the laboratory tests specified in the trial protocol. * If females of child bearing potential, patients must be using a highly effective method(s) of contraception and agree to do so from at least the screening visit until one month after administration of the final study dose. * The scar area to be revised is disfiguring. To be considered disfiguring for this trial scars must have at least one of the following characteristics. * Scar area 13 or more cm in length. * Scar area at least 0.6 cm wide at widest part. * Surface contour of scar area elevated or depressed on palpation. * Scar area adherent to underlying tissue. * Skin hypo-or hyper-pigmented in an area exceeding 39cm2. * Skin texture abnormal (irregular, atrophic, shiny, scaly, etc.) in an area exceeding 39cm2. * The scar to be revised is at least 12 months old. * The investigator considers that the appearance of the scar area to be revised can be improved with surgery alone. * The scar area is linear and suitable for revision by excision and direct closure. * The scar area to be revised is symmetrical in appearance around the mid-line. * The scar area to be revised is between 7 and 20cm in length. * The scar area to be revised runs along a flat surface which is in the same focal plane and suitable for accurate medical photography. * The scar is approved for entry into the trial by the Independent Expert Screening Panel. Exclusion Criteria * Patients who on direct questioning and / or physical examination, have evidence of any past or present clinically significant medical condition that would impair wound healing. * Patients with a creatinine clearance (CLcr) of 80ml/min or less. Creatinine clearance will be determined from the serum creatinine level at pre-study screening using the following formula : * CLcr = (140-age (years)) x weight(kg)/ 72 x serum creatinine (mg/dL) {x 0.85 for females} * Patients with a skin disorder that is chronic or currently active. * Patients who, in the opinion of the Investigator, have significant ongoing psychiatric disorders, which may interfere with the trial assessments / visits. * Patients with a history of clinically significant hypersensitivity to any of the drugs or surgical dressings to be used in this trial. * Patients who are taking, or have taken, any investigational drugs within 3 months prior to the screening visit. * Patients undergoing investigations or changes in management for an existing medical condition (excluding the scar for revision). * Patients who are or who become pregnant up to and including Day 0 or who are lactating. * In the opinion of the Investigator, a patient who is not likely to complete the trial. * Patients who on direct questioning and physical examination have history or evidence of keloid scarring. * Patients with scar areas for revision that cross a joint or are in close proximity to an anatomical structure, which could lead to distortion of the resultant scar or difficulty in taking photographs. * Patients with additional scars less than 3cm away from the area to be revised. * Patients with scars that require revision using Z-plasty, W-plasty or any other such techniques. * Patients who are involved in ongoing litigation in connection with the scar to be revised. * Patients who have had surgery in the area to be excised within one year of Day 0.