Microvascular Dilatation After Endogenous Induced Hyperinsulinemia

Maastricht University Medical Center48 enrolled

Overview

In this study we will examine if the insulin-induced microvascular effects will occur after a physiological stimulus (i.e. a oral glucose tolerance test). With that the physiological importance of the insulin-induced microvascular dilatation can be elucidated. In this study we hypothesize that oral glucose intake and consequently the endogenous induced hyperinsulinemia will lead to insulin-induced microvascular dilatation in healthy normotensive subjects. Furthermore, we suggest that the insulin-mediated microvascular dilatation, resulting from this physiological induced hyperinsulinemia, will be less in hypertensive and obese subjects compared to healthy controls.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Hypertension Obesity

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: healthy normotensive subjects: 1. 18-60 years 2. Caucasian 3. Blood pressure \<140/90 mmHg obese normotensive subjects: 1. 18-60 years 2. Caucasian 3. Blood pressure \<140/90 mmHg 4. BMI 30-38kg/m2 hypertensive subjects: 1. 18-60 years 2. Caucasian 3. Untreated hypertension \>140/90mmHg. Exclusion Criteria for healthy normotensive and hypertensive subjects: 1. Obesity (BMI\>27kg/m2) 2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 3. Diabetes mellitus according to the criteria of the ADA 4. Smoking 5. Alcohol use \>4U/day 6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs) 7. Pregnancy 8. Wearing contact lenses for normotensive obese subjects: 1. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 2. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA 3. Smoking 4. Alcohol use \>4U/day 5. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs) 6. Pregnancy 7. Wearing contact lenses