Safety, Tolerability and Pharmacokinetics of GSK1034702 in Healthy Subjects

Inclusion Criteria: * Healthy as determined by a responsible physician, based on a medical evaluation including own and familial medical history, physical examination, laboratory tests and cardiac monitoring. * Male or female between 18 and 55 years of age. * A female subject is eligible to participate if she is of non-childbearing potential * Body weight \> 50 kg and BMI within the range 19 - 29.9 kg/m2 (inclusive). * Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form. * Capable of reading, comprehending and writing English at a sufficient level to complete study-related materials. * Demonstrates no evidence of mental impairment. * No co-morbid Psychiatric Disorders as defined using the Mini International Neuropsychiatric Interview Exclusion Criteria: * A positive pre-study drug/alcohol screen. * A positive pre-study Hepatitis B , Hepatitis C or HIV. * History of regular alcohol consumption. * The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer). * Exposure to more than four new chemical entities within 12 months prior to the first dosing day. * Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements . * History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy. * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * Pregnant females, females planning pregnancy or lactating females. * Unwillingness or inability to follow the procedures outlined in the protocol. * History of sensitivity to heparin or heparin-induced thrombocytopenia. * Subjects with a current or a history of psychiatric illness. * Subjects with any history of suicidal attempts or behavior. * Urinary cotinine levels indicative of smoking or history or regular use of tobacco- or nicotine-containing products. * Consumption of red wine, seville oranges, grapefruit or grapefruit juice (and pummelos, exotic citrus fruits, grapefruit hybrids or fruit juices) from 7 days prior to the first dose of study medication.