Prospective Comparison of Immunological Benefit of Laparoscopic Colectomy

Samsung Medical Center84 enrolled

Overview

This study aimed to clarify existence of immunological benefit of laparoscopic colon cancer surgery compared to open colon surgery.

Patients with clinical stage Ⅲ left colon and upper rectal cancer were prospectively assigned to undergo LC (n=35) or OC (n=39). Factors related to cellular immunity of host (total lymphocyte count, CD4 lymphocyte, CD8 lymphocyte, CD4/CD8 ratio, HLA-DR expression on monocyte (mHLA-DR)) were examined preoperatively, on the 1st day of operation (POD1) and the 5th day of operation (POD5).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Immunity

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Biopsy proven of colon cancer * Preoperatively suspected as clinical stage III colon cancer * Lesion located Descending colon, sigmoid colon and upper rectal cancer Exclusion Criteria: * Could not perform curative resection * Intestinal obstruction, perforation, intra-abdominal abscess * Severe medical illness * Immunopathy

Locations (1)

Samsung Medical Center, Department of surgery

Seoul, South Korea

Outcomes

Primary Outcomes

Immune factors

Time frame: post OP 5th day

Secondary Outcomes

Post-operative complications

Time frame: POD 7th days

Data from ClinicalTrials.gov

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