Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo

Inclusion Criteria: * A glucose value of ≥140 mg/dl on a 50-gram oral glucose loading test by plasma at gestational age between 24 weeks 0 days and 27 weeks 6 days based on clinical information * An Abnormal 3-hour oral glucose tolerance test with a fasting glucose of ≤105 mg/dl * Gestational age of less than or equal to 28 weeks and 0 days at the time of consent/randomization * Singleton gestation Exclusion Criteria: * Established pregestational diabetes * Abnormal gestational diabetes testing (≥140) prior to 24 weeks 0 days of gestation. Women who have a negative glucose loading test (\<140mg/dl) before 24 weeks may still be considered for this study if they present again for glucose tolerance testing between 24 and 27 weeks. * Multiple gestations * Known major fetal anomaly or fetal demise * Any renal disease with serum creatinine of \>1.0 * Known liver disease such as hepatitis * Maternal or fetal conditions likely to require imminent or very preterm delivery such as preeclampsia, preterm premature rupture of the membranes, preterm labor, and intrauterine fetal growth restriction * Known hypersensitivity or allergic reaction to Glyburide