The Effect of Infliximab on Sperm Quality

Tel-Aviv Sourasky Medical Center100 enrolled

Overview

Background: The treatment of inflammatory bowel diseases (IBD) is based mainly on 3 compounds: 1- 5 aminosalysilates . 2- immunomodulators (Azathioprines). 3- Biologic therapies (Infliximab, Adalimumab) . There are no established data in the literature whether these therapies effects sperm quality. Given that a large number of the patients are young men in the reproductive stage of their lives , It of importance to investigate these effect. Aim: To investigate the effect of chronic treatment of any of the three therapy mentioned above, on sperm quality .

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Crohn's Disease Ulcerative Colitis

Interventions

sperm quality testOTHER

All participants will undergo sequential sperm quality tests and blood tests

Eligibility

Sex: MALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male above the age of 18 * Capable of giving informed consent * Diagnosed with IBD at least 3 months * Patients that are going to start a treatment with on of the following groups: 5ASA, Azathioprines, infliximab or ADAlimumab * Patients that are treated with therapies mentioned in article 4 for at least 3 months Exclusion Criteria: * Male younger than 18

Data from ClinicalTrials.gov

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