Measurement of MRP2 Function Using Urinary Coproporphyrins

University Hospital, Tours40 enrolled

Overview

Human Multidrug Related Protein 2 (MRP2) excretes several drugs and could therefore modulate their elimination. Individual's MRP2 activity is under genetic control. Thus it would be very useful to get an easily measurable biomarker reflecting individual's MRP2 activity. We aimed to investigate the ratio of urinary coproporphyrins I and III (UCP(I/I+III), known to be increased in patients with mutations in MRP2/ABCC2 gene.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy Subjects

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * \> 18 y * Affiliated to an health insurance Exclusion Criteria: * Patient not able to understand or to comply to the protocol

Locations (1)

CHRU de TOURS

Tours, France

Outcomes

Primary Outcomes

Urinary coproporphyrins (I/I+III)ratio

Time frame: End of three 24-hours periods

Secondary Outcomes

ABCC2 polymorphisms

Time frame: At the time of entering in the study

Data from ClinicalTrials.gov

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