Birch pollen allergy is one of the most common forms of respiratory allergy in the Nordic countries. Treatment consists of antihistamine use. Specific probiotic strains have been observed to modulate the immune system. Since the body has a common mucosal immune system; it was hypothesised that consumption of probiotics may affect also the respiratory mucosal immune response and hence affect respiratory allergy. Earlier studies with probiotics had been unable to show improvements in adults with pollen allergy. It was therefore hypothesised that children, who's immune system is not yet fully developed, might be better targets.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
47
Daily 5x10\^9 CFU of a combination of L. acidophilus and B. lactis
Microcrystalline cellulose As capsule which could be opened
Turku University Central Hospital
Turku, Finland
Birch pollen allergy symptoms
Time frame: March/April and June
Nasal Eosinophilia
Time frame: April/May and June
Change in microbiota composition
Time frame: April/May and June
Cytokine profile from serum
Time frame: April/May and June
Faecal recovery of administered probiotics
Time frame: April/May and June
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