Long-Term Outcomes in the Treatment of Infantile and Acquired Esotropia With Botulinum Toxin

National Taiwan University Hospital164 enrolled

Overview

To investigate long-term treatment outcomes of patients receiving botulinum toxin A therapy for infantile and acquired esotropia.

Participants: 164 patients with infantile esotropia and 89 patients with acquired esotropia. Methods: Patients were injected with botulinum toxin into two medial rectus muscles and followed from 1992 to 2005. Patients were evaluated at 1 week, 2, 6 and 12 months, and then yearly post-injection. Main Outcome Measures: Degree of motor alignment, recurrence rate, incidence of stereopsis, and dissociated vertical deviation along with complications.

Study Type

OBSERVATIONAL

Enrollment

164

Conditions

Esotropia

Eligibility

Sex: ALLMin age: 1 DayMax age: 5 Years

Medical Language ↔ Plain English

Inclusion Criteria: * infantile esotropia and acquired esotropia Exclusion Criteria: * exotropia, high AC/A ratio accommodative esotropia, patients with neurological deficit including cerebral palsy, Down syndrome and mental retardation, and ocular anomalies including retinopathy of prematurity. Patients lost to follow-up at 6 months or less after the last injection were also excluded.

Locations (1)

National Taiwan University Hospital

Taipei, Taiwan

Outcomes

Primary Outcomes

Degree of motor alignment, recurrence rate, incidence of stereopsis, and dissociated vertical deviation along with complications.

Time frame: Before treatment, weekly after the treatment, and monthly after motor alignment

Data from ClinicalTrials.gov

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