The purpose of this study is to determine if taking Vyvanse with Prilosec OTC or Adderall XR with Prilosec OTC changes how quickly the drug is absorbed into the body and/or changes how much of the drug is absorbed into the body.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
24
50mg capsule
20mg capsule
Clinical Pharmacology of Miami, Inc.
Miami, Florida, United States
Maximum Plasma Concentration (Cmax) of d-Amphetamine for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC
d-Amphetamine is an isomer of Vyvanse and Adderall XR and is an active form that is responsible for the drug's therapeutic activity.
Time frame: 0 through 96 hours after dosing
Time of Maximum Plasma Concentration (Tmax) of d-Amphetamine for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC
d-Amphetamine is an isomer of Vyvanse and Adderall XR and is an active form that is responsible for the drug's therapeutic activity.
Time frame: 0 through 96 hours after dosing
Area Under the Steady-state Plasma Concentration-time Curve (AUC) of d-Amphetamine for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC
d-Amphetamine is an isomer of Vyvanse and Adderall XR and is an active form that is responsible for the drug's therapeutic activity.
Time frame: 0 through 96 hours after dosing
Terminal Half-life (T 1/2) of d-Amphetamine for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC
d-Amphetamine is an isomer of Vyvanse and Adderall XR and is an active form that is responsible for the drug's therapeutic activity.
Time frame: 0 through 96 hours after dosing
Cmax of l-Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC
l-Amphetamine is an isomer of Adderall XR and is an active form that is responsible for the drug's therapeutic activity.
Time frame: 0 through 96 hours after dosing
Tmax of l-Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC
l-Amphetamine is an isomer of Adderall XR and is an active form that is responsible for the drug's therapeutic activity.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 0 through 96 hours after dosing
AUC of l-Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC
Time frame: 0 through 96 hours after dosing
T 1/2 of l-Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC
l-Amphetamine is an isomer of Adderall XR and is an active form that is responsible for the drug's therapeutic activity.
Time frame: 0 through 96 hours after dosing
Cmax of Total Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC
Total amphetamine is the d- and l-amphetamines.
Time frame: 0 through 96 hours after dosing
Tmax of Total Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC
Total amphetamine is the d- and l-amphetamines.
Time frame: 0 through 96 hours after dosing
AUC of Total Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC
Total amphetamine is the d- and l-amphetamines.
Time frame: 0 through 96 hours after dosing
T 1/2 of Total Amphetamine for Adderall XR Alone and in Combination With Prilosec OTC
Total amphetamine is the d- and l-amphetamines.
Time frame: 0 through 96 hours after dosing
Drug Rating Questionnaire-Subject (DRQ-S), Question 2, for Vyvanse and Adderall XR in Combination With Prilosec OTC.
Question 2: How much do you like the effects you are feeling now? Questions are rated on a 29-point scale from 1 (not at all) to 29 (an awful lot). The higher the score the stronger the subjective experience. This is a subjective measure of a drug's effect that has been used to assess the abuse potential of drugs.
Time frame: Pre-dose and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 12 and 24 hours after dosing
DRQ-S, Question 1, for Vyvanse and Adderall XR in Combination With Prilosec OTC
Question 1: How much do you feel the drug now? Questions are rated on a 29-point scale from 1 (not at all) to 29 (an awful lot). The higher the score the stronger the subjective experience. This is a subjective measure of a drug's effect that has been used to assess the abuse potential of drugs.
Time frame: Pre-dose and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 12 and 24 hours after dosing
DRQ-S, Question 3, for Vyvanse and Adderall XR in Combination With Prilosec OTC
Question 3: Do you dislike the drug effect you are feeling now? Questions are rated on a 29-point scale from 1 (not at all) to 29 (an awful lot). The higher the score the stronger the subjective experience. This is a subjective measure of a drug's effect that has been used to assess the abuse potential of drugs.
Time frame: Pre-dose and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 12 and 24 hours after dosing
Systolic Blood Pressure for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC
Time frame: Pre-dose and 1, 2, 4, 8, 12, 24, 48, 72 and 96 hours after dosing
Diastolic Blood Pressure for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC
Time frame: Pre-dose and 1, 2, 4, 8, 12, 24, 48, 72 and 96 hours after dosing
Pulse Rate for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC
Time frame: Pre-dose and 1, 2, 4, 8, 12, 24, 48, 72 and 96 hours after dosing
Electrocardiogram Results (QTcF Interval) for Vyvanse and Adderall XR Alone and in Combination With Prilosec OTC
QTcF is the QT interval using Fridericia's correction formula. QT interval is a measure of time between the start of the Q wave and the end of the T wave and is dependent on the heart rate(e.g., the faster the heart rate, the shorter the QT interval). The QT interval has to be corrected in order to aid interpretation.
Time frame: Pre-dose, 2 and 8 hours after dosing