A Capsular Incision and Biochemical Recurrence After Radical Perineal Prostatectomy

Samsung Medical Center266 enrolled

Overview

To evaluate the impact of capsular incisions on biochemical recurrence (BCR) and the potential risk factors of capsular incisions.

The pathological classification of the prostate following radical prostatectomy provides important prognostic information; an accurate pathology report is the cornerstone to cancer treatment and follow-up. In addition to the preoperative serum PSA, Gleason score on pathology specimens, seminal vesicle invasion and lymph node status, and a positive surgical margin with extraprostatic extension (EPE) are significant predictors of clinical and biochemical recurrence. However, the prognostic implication of a capsular incision, a tumor extending to the inked margins without a histologically documented EPE, remains to be defined.

Study Type

OBSERVATIONAL

Enrollment

266

Conditions

Radical Perineal Prostatectomy

Eligibility

Sex: MALEMin age: 43 YearsMax age: 78 Years

Medical Language ↔ Plain English

Inclusion Criteria: * pathologically proven prostate cancer * follow-up for at least 6 months Exclusion Criteria: * insufficient biopsy data * seminal vesicle invasion or lymph node involvement on pathology * neoadjuvant or adjuvant therapy

Locations (1)

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

biochemical recurrence of prostate cancer

Time frame: upto the final date of study

Secondary Outcomes

risk factors for capsular incisions

Time frame: at surgery

Data from ClinicalTrials.gov

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