Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single Doses of AZD8566.

Inclusion Criteria: * Provision of written informed consent. * Clinically normal physical findings and laboratory values as judged by the investigator with normal ECG * Females who are permanently or surgically sterile or postmenopausal. Exclusion Criteria: * Intake of medicine (except Hormone Replacement Therapy or occasional paracetamol) within 3 weeks before first administration of study drug * History of any convulsions or seizures * History of infection or at risk of infection due to recent surgery or trauma * History or presence of conditions known to interfere with the absorption, distribution, metabolism and excretion of the study drug