MRI Screening for Patients With Myelodysplastic Syndrome (MDS), Who Have Received Multiple Red Blood Cell Transfusions

Weill Medical College of Cornell University15 enrolled

Overview

A known risk of red blood cell transfusions is that it puts excess iron into the patient's body. Researchers are continually seeking the most effective method of measuring iron concentration. The purpose of this study is to determine how much iron has been deposited in a patient's heart and liver as a result of having received red blood cell transfusions using magnetic resonance imaging (MRI).

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Myelodysplastic Syndrome (MDS)

Interventions

T2* Cardiac and Liver MRIOTHER

Patients will undergo an MRI of the heart and liver.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or Female patients will need documentation of diagnosis of Myelodysplastic Syndrome by previous bone marrow exam * Male or female patients with MDS who have received at least 50 units of Red Blood Cell Transfusions. * Serum ferritin \> 1,000 * Written informed consent by the patient. Exclusion Criteria: * Contraindication to MRI, including cardiac pacemaker, brain aneurysm clip, implanted neurostimulator, insulin pump, cochlear implant, metal slivers in the eyes, intrauterine device or any other MRI incompatible metal implants or intractable claustrophobia.

Locations (1)

Weill Medical College of Cornell University

New York, New York, United States

Outcomes

Primary Outcomes

To evaluate the incidence of clinically significant cardiac iron overload in heavily transfused MDS patients using T2* MRI.

Time frame: A single T2* MRI will be performed on eligible patients.

Secondary Outcomes

Evaluate left ventricular ejection fraction as assessed by T2* MRI.

Time frame: A single T2* MRI will be performed on eligible patients.

Evaluate liver iron concentration as assessed by R2* MRI

Time frame: A single T2* MRI will be performed on eligible patients.

Data from ClinicalTrials.gov

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