Pilot Study for Patients With Poor Response to Deferasirox

Part I: Inclusion criteria for Inadequate responders * Male or female patients with transfusion dependent iron overload including patients with thalassemia syndromes, sickle cell disease and bone marrow failure. * Patients currently on Desferal (desferrioxamine) therapy will require a one day wash out prior to the first dose of study drug. * Dose of deferasirox: \>30 mg/kg/day of deferasirox for at least 3 months * No improvement or worsening of liver iron content (LIC) if this has been evaluated on deferasirox in the 3 months preceding the baseline studies. * Age greater than 6 years * Serum Ferritin: Ferritin \>1500 ng/ml and rising over three month period while on deferasirox. * Patients had to achieve 'failure' as described above previously and may or may not currently be on deferasirox and may currently be having adequate responses on doses greater than or equal to 35 mg/kg/day of deferasirox. * Life expectancy ≥ 6 months * Written informed consent by the patient or for pediatric patients consent of the patient's legal guardian. The definition of the term 'pediatric' for enrollment and study conduct will be in accordance with Children's Hospital IRB. Parents or the legal guardians will be fully informed by the investigator as to the requirements of the study. Pediatric patients themselves will be informed according to their capabilities in a language and in terms that they are able to understand. Written informed consent will be obtained from their legal guardian on the patient's behalf in accordance with national legislation. If capable, all patients should also personally sign their written informed consent. Part I: Inclusion criteria for good responders: * Male or female patients with transfusion dependent iron overload including patients with thalassemia syndromes, sickle cell disease and bone marrow failure. * Patients currently on Desferal (desferrioxamine) therapy will require a one day wash out prior to the first dose of study drug. * Serum ferritin less than or equal to 1000 ng/ml or declining over a 3 month period on a dose of less than 30 mg/kg of deferasirox. * Age greater than 6 years * Life expectancy ≥ 6 months * Written informed consent by the patient or for pediatric patients consent of the patient's legal guardian. The definition of the term 'pediatric' for enrollment and study conduct will be in accordance with Children's Hospital IRB. Parents or the legal guardians will be fully informed by the investigator as to the requirements of the study. Pediatric patients themselves will be informed according to their capabilities in a language and in terms that they are able to understand. Written informed consent will be obtained from their legal guardian on the patient's behalf in accordance with national legislation. If capable, all patients should also personally sign their written informed consent. Exclusion criteria for Part I: * Pregnancy (as documented in required screening laboratory test) or breast feeding * History of non-compliance to medical regimens or patients who are considered potentially unreliable and/or not cooperative * Patients with transfusion requirements equal to or more frequent than every three weeks. * AST or ALT \> 400 U/L during screening * Patients with uncontrolled systemic hypertension * Severe cardiac insufficiency (NYHA III or IV), with uncontrolled and/or unstable cardiac or coronary artery disease not controlled by standard medical therapy * Patients who received treatment with systemic investigational drug within the past 4 weeks or topical investigational drug within the past 7 days or are planning to receive other investigational drugs while participating in the study * Allergy to deferoxamine * Known contraindication to having a nuclear medicine study * Any other condition which in the opinion of the investigator would prevent completion of the trial. * Prior possible toxicity is not an exclusion criteria for Part I because patients require a chelating agent of which there are only two Patients who are found to be ineligible after screening procedures will have this documented on the screening log. No further data will be collected in the CRF for these patients. Exclusion criteria for Part II: * Patients with unacceptable toxicity to deferasirox such as renal failure or worsening cardiac function * Patients who have failed to achieve negative iron balance at the maximum tolerated dose of deferasirox * Patients who require an alternative chelator for specific reasons * Patients who are currently enrolled on conflicting therapeutic trials * Patients with serum ferritin less than 500 ng/ml at screening * Any other condition which in the opinion of the investigator would prevent completion of the trial