Efficacy and Safety Study of JTT-302 in Subjects With Low HDL-C Levels

Inclusion Criteria: * Subjects with a Body Mass Index (BMI)≤ 35 kg/m2 * Subjects with the following lipid parameters at Visit 1 (screening visit) and Visit 3 (diet stabilization period): * HDL-C ≤ 40 mg/dL (Men) and ≤ 50 mg/dL (Women) * TG ≤ 500 mg/dL * LDL-C ≤ 190 mg/dL * Subjects who are generally healthy as determined by pre-study medical history, physical examination, vital signs and 12-lead ECG Exclusion Criteria: * Females who are pregnant or breast-feeding * AST, ALT or total bilirubin ≥ 2.0 x ULN at Visit 1 (screening visit) or Visit 3 (diet stabilization period) * Serum thyroid stimulating hormone (TSH) and levothyroxine (T4) outside of the central laboratory reference range at the screening visit * Medical history of diabetes mellitus or two fasting serum glucose measurements \> 126 mg/dL at the screening visit * Subjects with hypertension, or two blood pressure measurements ≥ 140 mm Hg systolic or ≥ 90 mm Hg diastolic at the screening visit * History of drug or alcohol abuse within 12 months of the screening visit * Use of medications defined in the protocol within six-weeks prior to the screening visit and throughout the study * Use of Cytochrome P450 3A4 inducers or inhibitors, as defined in the protocol within four weeks of the screening visit and throughout the study