This study was intended to evaluate the effect of vitamin D supplementation on insulin sensitivity and pancreatic islet beta-cell function. Our hypothesis was that vitamin D supplementation to normal levels in patients with impaired fasting glucose will result in improved insulin sensitivity and improved beta cell function.
A modified frequently sampled intravenous glucose tolerance (mFSIGT) test was used. On day 0, baseline 22 time point mFSIGT was performed. Subjects were then treated with cholecalciferol (vitamin D3) supplementation - 10,000 IU/day - for 28 consecutive days. mFSIGT was then repeated measuring glucose, insulin and c-peptide at all time points. 25-OH vitamin D, PTH, and calcium were also measured at time point 0 pre and post vitamin D supplementation. Data was analyzed using the Bergman/Boston minimal model for insulin homeostasis with MinMod Millennium software.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
12
Oral capsules of cholecalciferol, 5000 IU/ capsule, two capsules daily for one month.
University of Minnesota, Division of Endocrinology
Minneapolis, Minnesota, United States
Assessment of insulin sensitivity before and after oral vitamin D3 supplementation with 10,000 IU/day for one month.
Time frame: At baseline and after 4 weeks of vitamin D supplementation
Monitor effect of vitamin D supplementation with 10,000 IU/day for one month on serum calcium and parathyroid hormone levels.
Time frame: One month
Assess effect of vitamin D supplementation on beta cell function as measured by analysis of data collected through a modified FSIGT test.
Time frame: One month
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