Low Dose hCG in the Late Follicular Phase

Universitair Ziekenhuis Brussel70 enrolled

Overview

In this study,the investigators compared two protocols for controlled ovarian hyperstimulation in infertility patients requiring IVF. In the control group, the patient undergoes a standard antagonist protocol. In the study group, the administration of gonadotropins is stopped in the late follicular phase and replaced by low dose human chorionic gonadotropins. The primary endpoint of the study is the number of oocytes retrieved in both groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Infertility

Interventions

human chorionic gonadotropinDRUG

hCG 200IU in the late follicular phase

recombinant gonadotropinsDRUG

200 IU per day during controlled ovarian stimulation

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 36 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \< 36 years on day of randomisation * FSH \< 12 in the early follicular phase * Normal ultrasound scan * BMI between 18 and 29 (both inclusive) * Randomisation at outpatient clinic Exclusion Criteria: * Endometriosis ≥ grade 3 * PCO syndrome * Poor responder * Endocrine or metabolic abnormalities

Locations (1)

UZ Brussel

Laarbeeklaan 101, Brussels Capital, Belgium

Outcomes

Primary Outcomes

Number of oocytes in both treatment groups

Time frame: up to 9 months

Secondary Outcomes

Duration of stimulation in both treatment groups, amount of gonadotropins consumed in each treatment group

Time frame: up to 9 months

Data from ClinicalTrials.gov

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