Low Molecular Weight Heparin in Recurrent Implantation Failure

V.K.V. American Hospital, Istanbul

Overview

Recurrent implantation failure is the failure to achieve a pregnancy after multiple attempts with in vitro fertilization treatment. The reason is usually obscure. Many empirical treatments have been offered without substantial evaluation. Heparin is thought to play a role in the embryo implantation process beyond its anticoagulation effects. The proposed study aims to assess the effectiveness and safety of empirical administration of low molecular weight heparin in patients undergoing a new IVF treatment cycle after multiple failed attempts.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Infertility Fertilization in Vitro Recurrent Implantation Failure

Interventions

low molecular weight heparin (enoxaparine sodium)DRUG

1 mg/kg/day subcutaneously in the luteal phase after IVF treatment

crinone 8% gelDRUG

routine luteal phase support with progesterone gel

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 38 Years

Medical Language ↔ Plain English

Inclusion Criteria: * History of at least two previously failed fresh embryo transfer cycles * All previously failed cycles to be performed in the American Hospital of Istanbul * Female age ≤ 38 years * Fresh ejaculate sperms to be used for ICSI * No hormonal, coagulation, or immunological disorders detected * Normal uterine cavity, as assessed by diagnostic office hysteroscopy or saline infusion sonography * Normal female and male peripheral karyotype

Locations (1)

Assisted Reproduction Unit of the American Hospital of Istanbul

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Ongoing pregnancy beyond the 20th gestational week rate

Secondary Outcomes

Clinical pregnancy rate

Embryo implantation rate

Data from ClinicalTrials.gov

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