Efficacy Study of "Go On" in Magnetic Resonance Imaging (MRI) Improvement in Osteoarthritis (OA) Knee

Inclusion Criteria: * Subjects who are capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form. * Ambulatory non pregnant females and males 40-\<80 years of age. * Subjects who withdraw pain medication or nutritional supplements for symptom relief for OA hand for a total of at least 30 days before screening visit 0. * Pain at or below 40 mm on a 100 mm VAS in the index knee joints. * A documented diagnosis of OA of the knee joint, or meeting American College of Rheumatology (ACR) clinical criteria for classification of idiopathic (primary) OA for at least 6 months prior to screening. * Subject has been documented radiographic evidence of OA of the knees from the screening Visit radiograph of grade 2 or 3 according to Kellgren and Lawrence Radiographic Grading. * Subject has no any contraindication for MRI * Subject is able to understand and complete pain/function, global arthritis evaluation, and health outcome assessment. Exclusion Criteria: * Subjects with history of hypersensitivity to hyaluronate. * Subjects with skin lesion at the knee joint. * A history of knee surgery within 6 months prior to screening V0. * Significant prior injury to the knee joint within 12 months prior to screening V0. * Disease of the spine or other lower extremity joints of sufficient degree to affect the knee joint. * Treatment with other drugs potentially affecting bone or cartilage metabolism as described below: * chronic systematic corticosteroids * Diacerin or glucosamine treatment within the last 12 months.