Effect of APL180 on Endothelial Function in Familial Hypercholesterolemia Patients

Novartis Pharmaceuticals

Overview

This study will evaluate the effect of APL180 on endothelial function measured by forearm venous occlusion plethysmography in patients with familial hypercholesterolemia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Conditions

Familial Hypercholesterolemia

Interventions

APL180DRUG

PlaceboDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Confirmed presence of familial hypercholesterolemia * Women must be sterilized or post-menopausal Exclusion Criteria: * Smoking an average of greater than 10 cigarettes per day * History of cardiac events * Very low or high body weight * Treatment with fibrates or niacin * High blood triglyceride levels Other protocol-defined inclusion/exclusion criteria may apply.

Outcomes

Primary Outcomes

Change in forearm blood flow during each treatment

Data from ClinicalTrials.gov

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