Faster recovery from anesthesia is important for obese patients because they are at high risk of respiratory complications following tracheal extubation. Isoflurane has several properties that make it a preferable agent for anesthesia in obese patients. Its main limitation is a longer recovery time due to slower elimination in comparison to other agents. Elimination of isoflurane from the lungs can be accelerated by increasing in patient's minute ventilation, which decreases the level of CO2 in blood (hypocapnia).Isocapnic Hyperpnoea (IH) is a method allowing increased ventilation and therefore enhancement of the elimination of inhalation agents while maintaining a normal blood CO2 level. The investigators will compare recovery time from isoflurane anesthesia in obese patients during standard anesthesia management protocol (control) to a group treated with IH.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
44
IH is a method of increasing alveolar ventilation (Va) while preventing the unwanted hypocapnia by addition of CO2 to the inhaled mixture.
Toronto General Hospital
Toronto, Ontario, Canada
Time from the end of anesthesia (turning isoflurane vaporizer off) to the readiness for Post Anesthesia Care Unit (PACU) discharge.
Time frame: Intraoperatively and Post Anesthetic Care Unit
Times from end of anesthesia to BIS exceeds 75, b) eye-opening to verbal command, c) extubation, d) readiness for leaving
Time frame: Intraoperatively and Post Anesthetic Care Unit
Sedation/Pain scores in the PACU.
Time frame: Intraoperatively and Post Anesthetic Care Unit
Change in exhaled isoflurane concentrations in the 1st hour postoperatively.
Time frame: Intraoperatively and Post Anesthetic Care Unit
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.