Treat Clozapine ( CLZ )-Resistant Schizophrenia Comparing CLZ + Haloperidol vs. CLZ + Electroconvulsive Therapy (ECT)

Khon Kaen University18 enrolled

Overview

Clozapine treatment resistant schizophrenia is still prevalent.The effectiveness of augmenting clozapine : one augmenting with haloperidol and the other with electroconvulsive therapy should be determined.This study is a randomized control trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Schizophrenia

Interventions

clozapine+haloperidolDRUG

clozapine 300-900 mg/d haloperidol 4-60 mg/d

clozapine,electroconvulsive therapyDRUG

clozapine 300-900 mg/d electroconvulsive therapy 4-12 times

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. schizophrenic patients diagnosed with schedules for clinical assessment in neuropsychiatry ( SCAN )in accordance with DSM-IV-TR or ICD-10 2. Resistant to at least 6 weeks of clozapine treatment in therapeutic dosage 3. Voluntary to participate the research protocol expressed by signing informed consent form Exclusion Criteria: 1. Patient does not volunteer himself or herself 2. Patient is having epilepsy, DM, cardiac disease, autistic disorder and illiterate 3. Patient is deaf, blind , dumb to obstruct good communication

Locations (1)

Department of Psychiatry.Faculty of Medicine.KhonKaen University.

Muang, KhonKaen, Thailand

Outcomes

Primary Outcomes

PANSS , HAM-D , CGI , AIMS Scores

Time frame: every 4 weeks for 24 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.