A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Simvastatin for at Least 4 Weeks.

Inclusion Criteria: * Males or females * \> or = to 18 years of age * On a stable dose of simvastatin for 4 or more weeks * LDL-C \> or = to 115 mg/dL and \< or = to 250 mg/dL * TG \< 300 mg/dL * Women are not pregnant or breast-feeding or planning to become pregnant * Women had a hysterectomy or tubal ligation or are post menopausal or are practicing an acceptable method of contraception Exclusion Criteria: * BMI \> 40 * Allergic to colesevelam HCl * History of swallowing disorder * History of gastrointestinal motility disorder * Any disorder that might interfere with the study * History of drug or alcohol abuse