Targeting Inflammation in Acute Coronary Syndrome Using Colchicine

Inclusion Criteria: * All patients with a diagnosis of acute coronary syndrome who are \> 18 years old and who do not have any contraindication to colchicine. Exclusion Criteria: * Contraindication to colchicine including any of the following: * hypersensitivity to colchicine * severe renal, hepatic or gastrointestinal disorder * blood dyscrasias (myelodysplasia cytopenias etc) * Concurrent use of moderate-strong CYP3A4 inhibitors (a complete list is appended in the full protocol) * Known severe liver disease and/or elevated transaminases \> 1.5x the upper limit of normal * Estimated GFR \< 50 ml/min * Pregnant or lactating women or women not protected by a reliable contraception method * Current treatment with colchicine at enrollment * Active infection or systemic inflammation eg active rheumatoid arthritis