Low molecular weight heparin (LMWH) is injected in the dialysis circuit at the start of the session. In the present study we compare 3 different methods of injection of LMWH: parameters of dialysis efficiency and clotting are measured. The study lasts 3 sessions for each patient.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
15
Injection of LMWH at the inlet line, at the start of the hemodiafiltration session
Injection of LMWH at the inlet line, 5 minutes after the start of the hemodiafiltration session
Injection of LMWH at the outlet line, at the start of the hemodiafiltration session
University Hospital Ghent
Ghent, Belgium
Anti-Xa activity at the end of the session
Time frame: 240 min after start
Anti-Xa activity during the session
Time frame: at start, 30 min, 120 min and 180 min
ETP during the session
Time frame: at start, 30 min, 120 min, 180 min and 240 min
Reduction ratio of urea
Time frame: after 10min, 180min and 240min
Reduction ratio of beta2microglobulin
Time frame: after 10min, 180min and 240min
Visual inspection of membrane and circuit
Time frame: After the hemodiafiltration session
pressure measurements along the circuit
inlet blood line, prefilter, transmembrane, outlet blood line
Time frame: during the session
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