The APPROPRIATE study will compare differences in functional capacity (peak VO2) between chronotropically incompetent patients randomized to receive rate responsive pacing driven by either the minute ventilation (respiration-based) sensor or an accelerometer (motion-based).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
566
Accelerometer sensor
Minute ventilation sensor
Cardiology Association of NE Arkansas
Jonesboro, Arkansas, United States
Genesis Heart Institute
Davenport, Iowa, United States
Mean Change in Functional Capacity (Peak VO2).
The APPROPRIATE Study compared differences in functional capacity (peak VO2) between CI patients randomized to receive rate responsive pacing driven by either the minute ventilation (respiration-based) sensor or by an accelerometer (motion-based) sensor. The mean change in functional capactity will be compared against baseline; changes from baseline will be measured.
Time frame: 1 month and 2 months post-implant
Changes in Heart Rate During Activities of Daily Living (ADL) Using a Lift and Carry Test
This outcome measure will be compared against baseline.
Time frame: 2 months post-implant
Metabolic Chronotropic Relationship (MCR) Slope
Time frame: 1 month and 2 months post-implant
Exercise Time
Time frame: 1 month and 2 months post-implant
VO2 at Ventilatory Threshold
Time frame: 1 month and 2 months post-implant
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