Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms

Phase 4CompletedNCT00757978

Hospital de Clinicas de Porto Alegre22 enrolled

Overview

Memantine as an add-on therapy to clozapine may improve schizophrenia negative symptoms and cognitive functioning.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

memantine 10mg twice a day

1 capsule of placebo twice a day

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Under clozapine with negative symptoms Exclusion Criteria: * Pregnancy * Lactation

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Score in Brief Psychiatric Raring Scale

Time frame: baseline, 4 weeks, 8 weeks, 12 weeks

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