RATIONALE: Studying samples of blood from healthy volunteers in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in healthy volunteers.
OBJECTIVES: * To obtain blood samples and simple epidemiological information on a population-based series of adult individuals without cancer. * To establish whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer by comparing the frequency of alterations in these genes with the corresponding frequency in a comparable series of cancer patients. * To examine the interactions between genetic and non-genetic risk factors. OUTLINE: This is a multicenter study. Participants complete a simple epidemiological questionnaire. Participants undergo blood sample collection. DNA is extracted from these samples for polymorphism analysis of low penetrance cancer susceptibility genes in the following related clinical trials: MREC-SEARCH-CANCER, MREC-SEARCH-PROSTATE, and MREC-SEARCH-BREAST. They may also be used in the analyses of the following related clinical trials: MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL. PROJECTED ACCRUAL: A total of 2,000 male and 2,000 female participants will be accrued for this study.
Study Type
OBSERVATIONAL
Enrollment
4,000
University of Cambridge Cancer Research UK
Cambridge, England, United Kingdom
RECRUITINGAcquisition of blood samples and epidemiological information
Investigation of whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer
Examination of the interactions between genetic and nongenetic risk factors
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