Methylphenidate Treatment of Cancer-Related Fatigue

Inclusion Criteria: * history of Cancer * MFI \>40 * Karnofsky Index \>=70 * outpatient * patient are able to give informed consent Exclusion Criteria: * treatment with psychostimulants in the past two weeks before screening * active tumor disease * depression (HADS \>10) * cachexia (BMI \<18kg/m2) * clinically relevant kidney disorders * clinically relevant liver disorder * pathological ECG-finding * high blood pressure * occlusive arterial disease * angina pectoris * cardiac arrhythmias * CHD * post heart-attack status * post stroke status * known elevated intra-ocular pressure * known enlarged prostates * latent and manifest hyperthyreosis * alcohol, medication or drug dependency in the past six months or manifest drug abuse * participation in a clinical study within the past 30 days * participation in this study at an earlier point in time * simultaneous participation in another clinical trial * women of child-bearing age without adequate contraception (contraceptives, intrauterine device , no sexual intercourse) * pregnancy (positive pregnancy test) or lactation period