Naltrexone SR and Fluoxetine Combination Therapy in Subjects With Obsessive-Compulsive Disorder

Inclusion Criteria: * Male or female subjects, 18 to 60 years of age (inclusive) * Outpatients with a current diagnosis of OCD that have received previous therapy * Negative serum pregnancy test as screening in women of child-bearing potential * If a woman of child-bearing potential, must agreed to use an acceptable and effective form of contraception * No clinically significant abnormality on electrocardiogram (ECG) * No clinically significant laboratory abnormality at screening * Negative urine drug screen * Must be considered reliable and possess a level of understanding that enables the subject to provide written informed consent and to comply with protocol procedures and schedule Exclusion Criteria: * Diagnosis of substance dependence * Diagnosis of substance abuse (except for nicotine and caffeine) * Serious or unstable medical illnesses * Lifetime history of bipolar disorder, schizophrenia or other psychosis, bulimia, anorexia nervosa, Pervasive Developmental Disorder (PDD), Asperger's Syndrome or the presence of antisocial or borderline personality disorder * Diagnosis of tic disorder or Tourette's Syndrome * Subjects diagnosed with impulse control disorder * Known sensitivity or allergic reaction to either naltrexone or fluoxetine * Any condition which in the opinion of the investigator or Sponsor makes the subject unsuitable for inclusion in the study * Immediate family of investigators, study personnel or Sponsor representatives