Effect of Stress on Heroin-Related Memory Retrieval

National Institute on Drug Dependence, China

Overview

The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

Study Type

INTERVENTIONAL

Conditions

Heroin Dependence Learning and Memory

Interventions

propranolol and cortisolDRUG

Eligibility

Sex: MALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence. Exclusion Criteria: * current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).

Locations (1)

National Institute on Drug Dependence

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts

Data from ClinicalTrials.gov

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