Pharmacokinetics and Pharmacodynamics of High Versus Standard Dose Rifampicin in Patients With Pulmonary Tuberculosis

Inclusion Criteria: * Participant has a newly diagnosed pulmonary tuberculosis, confirmed by a positive smear of at least two sputum specimens with ZN staining. * Participant is willing to be tested for HIV. * Participant is at least 18, but not more than 65 years of age at the day of the first dosing of study medication. * Participant is admitted to KNTH or KCMC during the intensive phase of TB treatment. * Participant is able and willing to attend to KNTH or KCMC regularly during the continuation phase of TB treatment. * Participant is able to understand and willing to sign the Informed Consent Form prior to screening evaluations. * Female participants should understand that it is important not to get pregnant during the study. They should agree on taking measures to prevent them from getting pregnant during the study. They should agree on taking measures to prevent them from getting pregnant, such as using a contraceptive device or barrier method. Exclusion Criteria: * Participant has been treated with anti-tuberculosis drugs during the past three years. * Participant's body weight is less than 50 kg. * Participant has abnormal liver function test or serum creatinine (defined as levels higher than the upper limit of normal). * Participant has a relevant medical history or current condition that might interfere with drug absorption, distribution, metabolism or excretion (i.e. chronic gastro-intestinal disease, Diabetes Mellitus, renal or hepatic disease, use of concomitant drugs that interfere with the pharmacokinetics of anti-TB drugs). * Participant is on anti-retroviral treatment at inclusion. * Participant has a CD4 count less than 350 cells/mm3. * Participant has a Karnofsky score of less than 40. * Participant is pregnant or breastfeeding. * Participant has a Multi Drug Resistant (MDR)-TB for which another than the standard treatment regimen is needed.