Long Term Follow up of a Cohort of Children With TCF2 Mutation:Evolution of Endocrine and Renal Function

N/AActive Not RecruitingNCT00760331

University Hospital, Limoges100 enrolled

Overview

Anomalies of renal development are well know for patients treated for MODY-5 diabetes due to TCF2 mutation.A recent study confirms the existence of pediatric patients having TCF2 mutation but presenting renal anomalies alone.Endocrine and renal evolution of these patients is unknown.The aim of this study is to follow a cohort of patients with TCF2 mutation and initially presenting renal anomalies alone.

Biologic analysis and renal ultrasonography once a year. After puberty or before kidney transplantation * Abdominal and pelvic MRI * Intravenous Glucose Tolerance Test

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Hepatocyte Nuclear Factor 1-beta

Eligibility

Sex: ALLMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients presenting an anomaly of renal development due to TCF2 mutation * Age\<18 years old Exclusion Criteria: * Anomaly of renal development without TCF2 mutation * Age≥18 years old * Parents or patients refusing to participate to the study

Locations (1)

CHU de Limoges

Limoges, France

Data from ClinicalTrials.gov

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