High Dose, Absorbed Dose Adjusted 90Y-ibritumomab With Peripheral Blood Stem Cells (PBSC) Support in B-cell Lymphoma

Inclusion Criteria: * Written informed concent * Age at least 18 years * WHO Performance status 0-3 * Histologically verified B-cell lymphoma * Diffuse large B-cell lymphoma and follicular grade III, failing an anthracycline containing regimen and patients not found suitable for a second line chemotherapy consolidated by high dose chemotherapy (HDCT) with stem cell support or radiotherapy * Transformed B-cell lymphoma, failing first line therapy and not suitable for high dose chemotherapy (HDCT) or with a history of HDCT with stem cell support * Follicular lymphoma grade II and I, and other indolent lymphomas must have failed second line treatment. * One of these treatments must have contained chemotherapy and rituximab, the latter either together with chemotherapy or as maintenance. * The lymphoma must require treatment, Mantle cell lymphoma, failing first line treatment,treatment required * Measurable disease and the tumor burden must be acceptable according to the investigator * Radiological studies must be performed and a unilateral bone marrow biopsy within 4 weeks before start of treatment * Bone marrow reserve likely to give a harvest of at least 2x10 6 peripheral CD34+ stemcells or the existence of such a harvest or a corresponding central harvest * Total bilirubin should not exceed 40 micromole/L * A GFR as measured by Cystatin C of 50 ml/min * HIV, Hepatitis B and C status known * Life expectancy of at least 3 months. Exclusion Criteria: * Known or clinical evidence of CNS involvement * Bone marrow involvement at harvest as measured by biopsy and flow cytometry * Subjects with prior radiation to a field that includes over or equal 25% of their red marrow, liver or lung or to both kidneys * Prior chemotherapy or radiotherapy within 4 weeks * Subjects who are pregnant or nursing * Pulmonary involvement, that is not negligible at the discretion of the investigator * Liver involvement of lymphoma * History of hepatitis B or C.