This trial is conducted in Asia. The aim of this clinical trial is to investigate the blood concentration of liraglutide (pharmacokinetics) as well as the effects on glucose and insulin (pharmacodynamics) after 21 days of daily subcutaneous injections (injected under the skin) of liraglutide or placebo. In addition, the safety and tolerability of liraglutide will be observed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
37
Liraglutide for s.c. injection once daily: dose step 1 (9 subjects)
Liraglutide placebo for s.c. injection once daily: dose step 1 (3 subjects)
Liraglutide for s.c. injection once daily: dose step 1, followed by dose step 2 (9 subjects)
Novo Nordisk Investigational Site
Beijing, Beijing Municipality, China
AUC 0-24h (last dosing day): Area under the plasma liraglutide curve from 0 to 24 hours after last dosing.
Time frame: After 21 days of treatment
AUC 0-24h: Area under the plasma liraglutide curve from 0 to 24 hours after first dosing, AUC0-24h (Day 1)
Time frame: After 1 day of treatment
Adverse events
Time frame: After 21 days of treatment
Hypoglycaemic events
Time frame: After 21 days of treatment
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Liraglutide placebo for s.c. injection once daily: dose step 1, followed by dose step 2 (3 subjects)
Liraglutide for s.c. injection once daily: dose step 1, followed by dose steps 2 and 3 (9 subjects)
Liraglutide placebo for s.c. injection once daily: dose step 1, followed by dose steps 2 and 3 (3 subjects)