Comparison of the Effect of Vytorin 10/80 Tablet Split Into 4 and Simvastatin 20 Milligrams on Low-density Lipoprotein (LDL) Cholesterol

Inclusion Criteria: * Subjects with an LDL-cholesterol greater than 100 mg/dL * Patients willing and able to provide signed informed consent Exclusion Criteria: * Patients receiving a statin (Lipitor, Crestor, Lescol, Simvastatin, or Pravachol) * Patients intolerant of statins * Patients receiving ezetimibe * Patients intolerant of ezetimibe * Patients receiving a niacin preparation * Stroke, TIA, myocardial infarction, unstable angina, percutaneous coronary intervention, coronary artery bypass surgery, or major surgery within 3 months * Cancer undergoing active treatment * Creatinine clearance \< 50 ml/minute * Active liver disease or persistent elevation of SGOT or SGPT \> 2 times the upper limit of normal level * Participation in any clinical study within the last 30 days * Drug addition or alcohol abuse within the past 6 months * Use of azole antifungal agents, amiodarone, fibrates or immunosuppressant drugs within the last 3 months * Active use of macrolide antibiotics or verapamil * Consumption of grapefruit juice on a daily basis * Patients unwilling or unable to provide informed consent * Patients with poor compliance * Women of childbearing potential