RLIP76 (Ral binding protein1) is a 76 kDa splice variant protein encoded by the human gene (RALBP1, 18p11.22). It is a multifunctional modular protein found ubiquitously from Drosophila to humans, in cells ranging from red blood cells to endothelial cells of the brain. Its expression more predominant in breast, heart, liver and less so in colon and brain parenchyma.
RLIP76 is shown to be over expressed in a variety of cancer cells. However, no study has yet been done on its expression on normal cells. The studies proposed in this project will study the expression of RLIP76 in blood cells of healthy human subjects in the population of North Texas region.
Study Type
OBSERVATIONAL
University of North Texas Health Science Center
Fort Worth, Texas, United States
University of North Texas Health Science Center
Fort Worth, Texas, United States
Expression of RLIP76 in red blood cells and white blood cells of 100 healthy human subjects.
Time frame: 3 years
To investigate the RLIP76 mediated transport of glutathione conjugates and chemotherapeutic drugs.
Time frame: 3 years
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