Antidepressant Drug Exposure and Risk of Suicide Attempt Resulting in Medical Intervention in US Adults

Eli Lilly and Company254,432 enrolled

Overview

The primary objective of the study is to estimate the incidence of suicide attempts resulting in a medical encounter or hospitalization in seven propensity matched cohorts of subjects: patients treated with duloxetine for depression, patients treated with one of three other antidepressants or antidepressant classes (venlafaxine, SSRIs, or TCAs) for depression, patients treated with multiple antidepressants for depression (either concurrently or consecutively), depressed patients with no pharmacologic treatment, and a non-depressed general population sample.

Study Type

OBSERVATIONAL

Enrollment

254,432

Conditions

Depression Suicide

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 years or older at index date * Have at least 6 months of continuous enrollment data prior to index date. * Have complete medical, facility, and pharmacy records (the latter of which will include complete quantity and days supplied information). Exclusion Criteria: * None

Antidepressant Drug Exposure and Risk of Suicide Attempt Resulting in Medical Intervention in US Adults

Overview

Conditions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes