Norepinephrine Weaning in Septic Patients

Association pour le Développement de la Recherche et de l'Enseignement en Médecine d'Urgence40 enrolled

Overview

The weaning rate of vasopressors drugs is usually chosen empirically by the clinician in critically patients. The investigators applied fuzzy logic principles to modify intravenous norepinephrine infusion rates during norepinephrine infusion in septic patients in order to reduce the duration of shock. The investigators goal was to reduce the duration of poorly controlled hemodynamic status.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Septic Shock

Interventions

norepinephrine infused at the clinician's discretionDEVICE

norepinephrine infused under computerized fuzzy logic controlDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Septic shock Exclusion Criteria: * Less than 18 years * Pregnancy * Weight above 135 kg * Requirement for continuous epinephrine infusion * Severe head injury, stroke, a comatose state following cardiac arrest

Locations (1)

Réanimation

Bobigny, Seine-Saint-Denis, France

Outcomes

Primary Outcomes

Time to shock resolution defined as cessation of vasopressor support

Secondary Outcomes

28 days survival, total amount of norepinephrine infused, duration of mechanical ventilation, and length of stay in the ICU

Data from ClinicalTrials.gov

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