Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators conducted the study in comparing patients undergoing traumatologic, visceral or plastic surgical procedures. The investigators randomized them to four groups receiving common analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after first intake. The investigators compared the aggregation via aggregometry of platelet rich plasma.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
80
Dipyrone is given in the operation room with 2,5 g intravenously, followed by an oral regime of 4x1g on the ward
Ibuprofen is given orally 600mg in the Post Anesthesia Care Unit, followed by an oral regime of 800mg twice a day
Acetaminophen is given 1g intravenously in the Operation room, followed by an oral regime of 1g fourth a day
Acetaminophen is given 1g intravenously in the operation room, followed by 1g orally fourth a day
40mg Parecoxib are given intravenously in the operation room, followed by 40mg of Valdecoxib orally twice a day
Blood samples for aggregometry are taken before induction of anesthesia, 1h after first drug intake, 4hs and 24hs after first intake
BG University Hospital Bergmannsheil GmbH
Bochum, Germany
Percentage of aggregation in platelet rich plasma fter 24 hours of treatment with analgetic doses
Time frame: 24 hours
Percentage of aggregation of platelet rich plasma 1hour and 4 hours after initiation of study drug
Time frame: 4 hours
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