A Prospective, Open, Non-randomized Phase I/II Study of Therapeutic Angiogenesis in Diabetic Patients With Critic Ischemia of Lower Limbs While Administering Positive CD133 Mobilized With G-CSF

Inclusion Criteria: * According to the investigator opinion, patient is able to carry out with all the clinical trial requirements * Patient must volunteer sign the inform consent before any study specific test, that is not part of the common patient attention, is performed. Patient must know that he/she can abandon the study at any time with no damage to his/her posterior attention * Age 18 to 75 * A diagnosis of chronic critic ischemia of the lower limbs * Diabetes Mellitus active * III or IV stages (Fontaine classification): resting pain, ulcer or minor gangrene with no major amputation * General contraindication or local inoperability or refractory/progression after previous surgical treatment, according to the investigator criteria * If female reproductive potential, negative pregnancy test Exclusion Criteria: * Pregnant or currently breast feeding women * Acute myocardial infarction within the last 3 years * Non re-vascular unstable angina pectoris * History of ischemia stroke within the last 3 years * Neoplasia at the time of inclusion or Chemotherapy or Radiotherapy treatment in the last 5 years * Chronic renal insufficiency * G-CSF contraindication * A non well controlled serious concomitant disease * History of serious thrombotic episodes within the past 3 years * Patients who have received other investigational therapy within 30 days previous to the study inclusion * Patients currently in other clinical trial or receiving any other investigational agent