Intravenous Ketorolac for Postoperative Pain in Percutaneous Nephrolithotomy

Mayo Clinic17 enrolled

Overview

The purpose of this study is to determine whether continuous intravenous ketorolac infusion reduces pain in patients who are having percutaneous nephrolithotomy for kidney stone disease.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Renal Calculus Kidney Stones

Interventions

KetorolacDRUG

90 mg ketorolac in 1 L of normal saline infused at 40-120 mL/hr for 18.5-23 hours beginning 0.5 hours after the end of surgery.

PlaceboDRUG

1 L of normal saline infused at 40-120 mL/hr for 18.5-23 hours beginning 0.5 hours after the end of surgery.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing percutaneous nephrolithotomy for kidney stone disease Exclusion Criteria: * History of nonsteroidal antiinflammatory drug allergy * Asthma * History of long-term opioid use * Intraoperative blood loss greater than 300 mL * Postoperative hemodynamic instability * Active peptic ulcer disease * Advanced renal impairment (Creatinine \> 2.0 mg/dL) * Bleeding diathesis * Current use of probenecid * Pregnancy

Locations (1)

Mayo Clinic

Phoenix, Arizona, United States

Outcomes

Primary Outcomes

Pain 'Right Now'

Visual analog scale score for pain on a scale from 0 = None to 10 = Worst.

Time frame: 24 hours after the end of surgery

Morphine Equivalents of Concomitant Pain Medication

The morphine equivalent is a unit of measure to compare the efficacy of different types of opioids (narcotics). The patients were allowed to take additional pain medication in addition to either study drug or placebo. This outcome measure reports the amount of morphine (in mg) equivalent to the amount of concomitant pain medication used by the patient.

Time frame: 24 hours after the end of surgery

Data from ClinicalTrials.gov

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