A Study to Examine the Effects of Minocycline Extended-Release Tablets on Sperm Production in Human Males.

Inclusion Criteria: * Males at least 18 years of age * Weight 45 kg - 136.36 kg (99-300 lbs) * Must understand and give consent voluntarily to be in the study and to comply with study requirements * Subjects must ejaculate between 48 and 72 hours prior to collection of the first specimen (Pre-Collection Ejaculation) and refrain from further ejaculation until Specimen 1 is collected. The second ejaculation sample Specimen 2) must be collected between 48 hours and 72 hours after Specimen 1. No ejaculation is permitted between Specimen 1 and Specimen 2 * Must refrain from using saunas or hot tubs during the duration of the study 168 days) * Must be a non smoker * Must be medically healthy as determined by the investigator physician (via medical history and clinical laboratory tests) * Must have sperm parameters (average of Specimen 1 and Specimen 2) within clinically acceptable limits at screening defined as: * Total sperm concentration ≥20 x 106/mL10 * % motile ≥50%10 * % normal morphology \>4.4%14 Exclusion Criteria: * Known allergy/sensitivity to minocycline or any of the other drug product components * Use of antacids or other dietary supplements containing aluminum, calcium, iron, or magnesium * History of vestibular incidents including vertigo, lightheadedness, nausea, or vomiting within the 30 days prior to enrollment * Known history of alcohol or drug dependency, significant within the past 2 years * Known history or current risk of hepatic dysfunction * Known history or current risk of renal dysfunction, e.g., uncontrolled diabetes * Systemic lupus erythematosis (SLE) or a positive ANA at screening * Receipt of any experimental drugs within 120 days prior to Study Day 0 * Non-LFT clinical laboratory values outside the normal range and determined to be of clinical significance * Liver function tests greater than 1.5 times the upper limit of normal (ALT, AST, GGT) * Use of tetracyclines, erythromycin within 12 weeks of Day 0