Ghrelin Changes After Roux-en-Y Gastric Bypass

Vanderbilt University14 enrolled

Overview

The purpose of this study is to determine whether gastric division (via Roux-en-Y gastric bypass) with resultant fundic isolation will alter the pattern(s) of Ghrelin secretion in the early post-operative period following feeding in morbidly obese subjects.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity Insulin Resistance

Interventions

Liquid diet for 3 daysOTHER

The control group were given a 3 -day liquid diet similar to the RYGB post-op diet

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Serum creatinine and liver function tests \< upper limits of normal * Stable body weights for the past three months * Women will have a negative pregnancy test * patients who are already scheduled for RYGB with gastrostomy tube placement Exclusion Criteria: * Significant hepatic enzyme elevations (more than 100% of upper limits of normal) * Serum creatinine \> 1.5 mg/dl * history of ketoacidosis or current metabolic acidosis * current use of oral anticoagulants * Positive pregnancy test (beta-human chorionic gonadotrophin) for females * intercurrent infections * patients with prior gastric operations

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

Ghrelin

Time frame: pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op

Secondary Outcomes

HOMA

Time frame: pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op

metabolic hormones

Time frame: pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op

Data from ClinicalTrials.gov

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