Ranibizumab in Combination With Proton Beam Irradiation for Choroidal Melanoma

Inclusion Criteria: * Patients with newly diagnosed choroidal melanoma undergoing proton therapy * Tumors \>15 mm in largest diameter and/or \>5 mm in height * Tumors ≤ 15 mm in largest diameter and ≤ 5 mm in height located ≤ 3 mm from optic disc and/or macula, with best-corrected visual acuity 20/100 or better in study eye Exclusion Criteria: * History of prior treatment for choroidal melanoma * Pregnancy or lactation * Presence of diabetic retinopathy * History of retinal vascular occlusion or other retinal vascular disease * Active ocular inflammation or history of uveitis in either eye * History of uncontrolled glaucoma (defined as intraocular pressure \>30mmHg despite treatment with anti-glaucoma medication) or filtering surgery in the study eye * Previous intravitreal injections of Avastin® in the study eye or in the non-study eye within 30 days. * Concurrent use of systemic anti-VEGF therapy