The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity. Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population. It is even associated with sleep apnea/hypopnea.
The main goal of this SYNAPSE study is to evaluate, on a selected prospective cohort of subjects aged 67 years upon study entry, the incidence of sleep apnea/hypopnea and the prognostic values of ANS activity levels measured at preset times and of cardiovascular or cerebrovascular events.
Study Type
OBSERVATIONAL
Enrollment
852
Simultaneous 24-hour ambulatory electrocardiogram and polygraphic recordings performed at home during a night.
Centre Hospitalier de Saint-Etienne
Saint-Etienne, France
Composite criterion : fatal and non-fatal cardiovascular or cerebrovascular events
Time frame: During all the study
Presence and relationship of sleep apnea/hypopnea and clinically silent stroke revealed through brain MRI
Time frame: Years 1, 3, 5, 7 and 9
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