Diabetes and Metabolic Postprandial Responses

Centre de Recherche en Nutrition Humaine Rhone-Alpe24 enrolled

Overview

The aim of this trial was to compare postprandial metabolic response to glucose load in healthy overweight and type 2 diabetic subjects, by using glycemia, insulinemia, lipid profile, nutrient oxidation follow-up. Stable isotopes of glucose were used to assess postprandial total,exogenous and endogenous glucose kinetics.

Study Type

INTERVENTIONAL

Masking

SINGLE

Enrollment

Conditions

Type 2 Diabetes Overweight

Interventions

oral glucose loadOTHER

oral ingestion of 13C labeled glucose

Eligibility

Sex: ALLMin age: 30 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Overweight or obese volunteers * Healthy for one group nd type 2 diabetic for the second group * Age between 30 and 65 years old * Total cholesterol \< or = 7 mmol/l and triglycerides \< or = 4 mmol/l * For diabetic group: treated by metformin and/or sulfonylurea and/or thiazolidinedione and HbA1c \< 6% * Stable weight over last 3 months * Informed consent Exclusion Criteria: * No compliant subjects * Participation in an other trial 2 months before starting this one * Ward of court or under guardianship (sheltered adults) * Person deprived of freedom by judicial or administrative decision * Type 1 diabetes and type 2 diabetes treated bu insulin or acarbose * Existence of a previously diagnosed pathology (other than type 2 diabetes) * Previous gastro-intestinal pathology * Treated by corticoids, anorexigens, weight loss medicines * Alcoholism or severe tobacco consumption

Locations (1)

Centre de Recherche En Nutrition Humaine Rhone Alpes

Lyon, France

Outcomes

Primary Outcomes

Apparition of exogenous glucose in plasma in the postprandial phase and its effect on carbohydrate and lipid metabolism

Time frame: 6 hours postprandially

Secondary Outcomes

Postprandial concentrations of glucose, non esterified fatty acids, insulin and triglycerides

Time frame: 6 hours postprandially

Carbohydrate and lipid oxidation

Time frame: 6 hours postprandially

Data from ClinicalTrials.gov

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