A Study in the Treatment of Acute Mania

Inclusion Criteria: * Diagnosis of bipolar I disorder and currently display an acute manic or mixed episode (with or without psychotic features) * Patients must have a Y-MRS total score of greater or equal to 20 at visit 2 * Patients must have experienced at least one manic or mixed episode prior to study enrollment * Female of childbearing potential must be using a medically accepted means of contraception, or practice sexual abstinence * Each patient must have a level of understanding sufficient to communicate intelligently with study personnel * Patients must be considered reliable * Each patient must understand the nature of the study and signed informed consent Exclusion Criteria: * Female patients who are pregnant or lactating * Serious, unstable illnesses such that hospitalization for the disease is anticipated within 3 month or death is anticipated within 3 years * Uncorrected hypothyroidism or hyperthyroidism * Narrow-angle glaucoma * History of allergic reactions or intolerance to study medications * DSM-IV substance dependence within the past 30 days at the judgement of the investigator * Judged clinically to be at serious suicidal risk * Treatment with an injectable depot neuroleptic within less than one dosing interval between depot neuroleptic injections prior to visit 2 * Any patient treated with clozapine within 4 weeks prior to visit 2 * Subjects who have received treatment with ECT within one month prior to visit 1